Dr. Kahler received his MD degree from Duke, trained in Pediatrics at UCSD (where he learned about inborn errors from Dr. Bill Nyhan), then trained in clinical and biochemical genetics at UNC-Chapel Hill.   Throughout his career he has been a clinician-educator, seeing patients and teaching, but he has always had strong affiliations with research physicians and scientists.  He worked at Duke from 1983-1997, in the division of Genetics and Metabolism directed by Dr. Roe.  He was part of the team there that developed what is now called expanded newborn screening, with funding obtained from the state of North Carolina.  He moved to Melbourne, Australia to direct the Victorian Clinical Genetic Services in 1998, returned to the US (Johns Hopkins) in 2003, and moved to Arkansas in 2005, where he succeeded Dr. Gibson.  He has served on newborn screening advisory committees in five states.  He has been interested in autism for many years, particularly the children who are responsive to diet changes, as they are similar in this way to children with defined inborn metabolic errors.   In Arkansas he is working closely with Jill James, PhD, on biochemical aspects of autism, particularly involving vitamin B12, folate, and glutathione.  He has written many articles and book chapters, and is co-author of the Handbook of Inherited Metabolic Diseases, with Georg Hoffman, Johannes Zschocke, William Nyhan, and Ertan Mayatepek.